Application

Detect CD138 using this Milli-Mark Anti-CD138-PE Antibody, clone MI15 validated for use in FC.

General description

CD138 is a transmembrane proteoglycan, bearing heparin sulphates and sometimes chondriotin sulfates. It consists of a 30.5 kDa core protein with 5 putative glycosaminoglycans attachment sites. CD138 is a member of the syndecan family. The reported Mr of CD138 ranges from 85,000 to 92,000, presumably depending on the glycosaminoglycan pattern of the molecule (Wijdenes, 1997). Within the hematopoietic system, CD138 is mainly confined to late stages of B-cell differentiation. It is typically expressed at high cellular density in plasma cells (Gattei, 1999). In mature tissues, CD138 is expressed by simple and stratified epithelia, fibroblasts, stratified keratinocytes and endothelial cells (Wijdenes, 1997). Anti-CD138, MI15, was included in the Sixth International Workshop and Conference on Human Leucocytes Differentiation Antigens, and studies by a number of different laboratories confirmed its reactivity with CD138 (Wijdenes, 1997).

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Quality

Evaluated by flow cytometry using U266 cells

Specificity

Antibody recognizes Human CD138 antigen

Target description

85-92 kDa (Wijdenes, 1997)